Results
| PMID | 23061744 |
| Gene Name | VEGFA |
| Condition | Endometriosis |
| Association |
Associated |
| Mutation | VEGF gene -460C/T (rs833061), +405G/C (rs2010963), +936T/C (rs3025039) polymorphisms |
| Population size | 5493 |
| Population details | 5493 (2690 cases, 2803 controls) |
| Sex | Female |
| Other associated phenotypes |
Endometriosis |
|
Ann Hum Genet. 2012 Nov;76(6):464-71. doi: 10.1111/j.1469-1809.2012.00726.x. Xu, Shaohua| Wu, Wei| Sun, Hong| Lu, Jing| Yuan, Beilei| Xia, Yankai| De Moor, Bart| Marchal, Kathleen| Wang, Xinru| Xu, Peizhen| Cheng, Wenjun Changzhou Maternal and Child Health Hospital, Affiliated to Nanjing Medical University, Changzhou 213000, China. Published data on the association between the vascular endothelial growth factor (VEGF) gene -460C/T (rs833061), +405G/C (rs2010963), +936T/C (rs3025039) polymorphisms and endometriosis risk are inconclusive. Eleven eligible case-control studies including 2690 cases and 2803 controls were included in this meta-analysis through searching the databases of PubMed and CBMdisc (up to August 1, 2011). In the overall analysis, no significant association between the -460C/T and +405G/C polymorphisms and risk of endometriosis was observed. However, significant associations were observed between endometriosis risk and VEGF+936T polymorphism with summarized odds ratio of 1.19 (95%CI, 1.02-1.37), 1.18 (95%CI, 1.03-1.37), 1.15 (95%CI, 1.01-1.30) for CT versus CC genotype, dominant mode (CT/TT vs. CC) and allele comparison (T vs. C), respectively. Furthermore, stratified analysis showed that significantly strong association between +936T/C polymorphism and endometriosis was present only in stage III-IV (OR = 1.32 for dominant mode; OR = 1.30 for T vs. C), but not in stage I-II. However, no significantly increased risk of endometriosis was found in any of the genetic models in Asians or in Caucasians. This meta-analysis supports that VEGF+936T/C polymorphism is capable of causing endometriosis susceptibility. Mesh Terms: Endometriosis/*genetics| Female| *Genetic Predisposition to Disease| Humans| Odds Ratio| *Polymorphism, Single Nucleotide| Publication Bias| Vascular Endothelial Growth Factor A/*genetics|DA 2013/03/12 06:00 |
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